Which of the circumstances below most accurately describes conditions that are likely to permit a robust anti-tumor adaptive immune response?

1.A tumor with high expression of proteins that have mutations in sequences encoding HLA-binding peptides.

2. A robust acute inflammatory response to PAMPs expressed specifically by tumor cells.

3. Anti-tumor T lymphocytes that have high expression of CTLA-4.

4.A tumor with high expression of PD-L1.